Michigan State (3-0, 1-0 Big Ten) plays at Boston College (2-1, 1-0 ACC) on Saturday (8 p.m., ACC Network) to kick off a very difficult stretch of the schedule. Here are five things to watch in the game and a final score prediction:

Seventh-ranked Missouri opens SEC play against Vanderbilt on Saturday. The Tigers are coming off a win over then-No. 24 Boston College in which they were slow at the start but came on strong, and ultimately overcame three unsportsmanlike conduct penalties.