Biologists have discovered an aberrant protein that's deadly to bacteria. This erroneously built protein mimics the action of aminoglycosides, a class of antibiotics. The newly discovered protein ...

This cartoon shows the newly identified mefloquine binding site causing the changes in the ribosome's dynamics which promote read-through of the premature stop codons. The main interactions are shown ...

Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory and their collaborators have discovered a protein that’s deadly to bacteria. The newly discovered protein could serve as a ...

This is a preview. Log in through your library . Abstract During protein synthesis, nonsense mutations, resulting in premature stop codons (PSCs), produce truncated, inactive protein products. Such ...

The antimalarial drug mefloquine could help treat genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, as well as some cancers. In these diseases, a mutation in the genetic code ...

Life just got more difficult for those fighting antibiotic-resistant superbugs. Researchers at McGill University have discovered two enzymes that use a never-before-seen mechanism to confer resistance ...

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the neurochemical ...