New research has identified the pain pathways between the gut and brain Researchers have identified the nerve pathways responsible for pain signals from the bowel to the brain, paving the way for new ...

Spontaneous pain is a hallmark of chronic pain disorders, but its assessment remains limited by the lack of objective biomarkers. Here we used precision functional magnetic resonance imaging data, ...

"By pinpointing these pathways, we now know how signals from the gut are being transferred and processed in the nervous system appropriately, giving us a clear guide of what neural pathways to target ...

Pain remains poorly understood in task-free contexts, limiting our understanding of its neurobehavioral basis in naturalistic settings. Here, we use a multimodal, data-driven approach with ...

A new editorial paper titled "Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability" has been published in Oncotarget. In this new editorial, researchers ...

Deep in our cells, a wide range of processes are occurring constantly. These cellular processes rely on enzymes to act as catalysts and set off a series of molecular interactions. There are still many ...

Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes, and ...

Physical pain is essential for survival, as it allows animals to detect when they are injured or unwell, seek shelter and address their ailments. Yet when it becomes chronic, pain can also become ...

Empathy—the ability to share and understand the emotions of others—is a cornerstone of human social interactions. When we witness someone in pain, we often experience a mirrored emotional response, a ...

Pain in sickle cell disease is frequently misunderstood, leading to mistrust between patients and providers. Many patients report managing their pain crises at home, because they fear being dismissed, ...