Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude ...
In humans, hundreds of proteins interact in a complex network dubbed the interactome. Those interactions are further complicated when disease-causing mutations are introduced into genes that code for ...
An international team led by researchers at the University of Toronto and the Broad Institute of MIT and Harvard has assembled the first large-scale, publicly available map to show the impact of ...
BUFFALO, N.Y. — A hallmark of Parkinson’s disease is the buildup of Lewy bodies — misfolded clumps of the protein known as alpha-synuclein. Long before Lewy bodies form, alpha-synuclein can interfere ...
Researchers in the RIKEN Center for Brain Science (CBS) examined the genetics of autism spectrum disorder (ASD) by analyzing mutations in the genomes of individuals and their families. They discovered ...
Researchers and medical experts have long tried to understand why some viruses remain harmless in animals while others jump ...
ALS is linked to toxic TDP-43 protein clumps. A new strategy targets a specific protein region. A small molecule, XL20, prevents clumping, reducing nerve damage in human cells. XL20 extended survival ...
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