As the 49ers prepare for Sunday’s matchup against the Tennessee Titans, McCaffrey’s availability has become a storyline. Earlier in the week, he battled an illness that limited his practice time, though he was able to log a full session on Friday.

RB Christian McCaffrey is expected to play vs. the Titans despite a questionable tag, with multiple NFL insiders signaling good news.

The San Francisco 49ers are back at Levi’s Stadium in Week 12 of the NFL season with a “Monday Night Football” matchup set against the Carolina Panthers.

RB Christian McCaffrey is not guaranteed to play in Sunday's game vs. Titans following the latest injury report

The San Francisco 49ers, led by quarterback Brock Purdy, face the Cleveland Browns, led by quarterback Shedeur Sanders, on Sunday, Nov. 30, 2025 at Huntington Bank Field in Cleveland, Ohio.

Get ready for the NFL on Christmas Day 2025 with the full schedule of games, how to watch, top matchups, and storylines to keep your eyes on.

Special teams delivering: Skyy Moore has come on to be the 49ers' best punt returner since John Taylor. Eddy Pineiro is healthy and locked in. The Niners are poor in field position on the year, ranking 31st, but in the closing stretch and the playoffs, special teams should be an asset. For once.

Dive into our NFL predictions for Shedeur Sanders' second start, a matchup between the San Francisco 49ers and Cleveland Browns.

The 49ers are back on track and could continue to roll in the weeks ahead. San Francisco (7-4), which already has benefited from a favorable 2025 NFL regular-season schedule, has entered a five-week stretch that could help bolster its record for the ...

The Los Angeles Rams host the Detroit Lions in Week 15 of the 2025 NFL season on Sunday. There are several ways fans can watch and stream Sunday's game. The Lions (8-5) avoided losing consecutive games for the first time since the 2022 season with a 44-30 win over the Dallas Cowboys last week.