The injury, if significant, has the potential to impact the 49ers not just for Sunday's game but as they attempt to secure the No. 1 seed in the NFC and into the playoffs.

But it’s not all good news for the 49ers. Left tackle Trent Williams was shaken up on the first play from scrimmage — Purdy’s pick-six — and is questionable to return with a hamstring injury. Austen Pleasants came in to replace him.

After a powerful 15-yard run by Brian Robinson Jr., Brock Purdy takes matters into his own hands. He rolls out to his left, sees nothing developing and takes off, eventually diving into the end zone for a 10-yard touchdown run, hitting a little dance afterwards in celebration. San Francisco's offense is rolling again after the early Purdy turnover.

Williams (hamstring) is questionable to return to Sunday night's contest against the Bears. Williams suffered a hamstring injury on the team's first offensive play of the game, and his status for the rest of the contest is now in question. In his absence, Austin Pleasants has taken over at left tackle versus Chicago.

The move would be to give him a bit of a front-loaded extension. Williams would get a raise and would get cash immediately due to the signing bonus. He would also be signed for 2026 and 2027. Yes, it puts the 49ers on the books for a potential 39-year old left tackle, but it drops the 2026 cap hit down significantly.

LT Trent Williams admitted his long-time touchdown dream has “faded” after a bizarre Titans moment, as San Francisco heads to the Colts.

As the San Francisco 49ers push toward the final stretch of the season, veteran left tackle Trent Williams has made one thing clear: this year’s Super Bowl opportunity carries real weight. With Super Bowl LX looming, Williams believes the work being done now, especially up front, can define the team’s legacy.