A newly discovered brain protein linked to Parkinson’s offers hope for targeted therapies that could slow or prevent disease progression in the future.

Normally, the SOD1 protein provides protective benefits to the brain but, in Parkinson's patients, it becomes faulty, causing the protein to clump and damage brain cells.

Wild-type SOD1 exists as a dimer with bound Cu and Zn, while mutants are misfolded, unable to dimerize or unable to efficiently bind Zn. a, Mutant SOD1 toxicity may result from aberrant oxidative ...

A team at the University of Sydney's Brain and Mind Center has discovered that a malfunctioning form of the protein SOD1 plays a key role in the progression of Parkinson's disease, according to a ...

A new drug originally developed to treat a different brain disease is now showing signs that it could help people with ...

SOD1-G93A (congenic): This congenic line is derived from the original hybrid line by backcrossing to C57BL/6J mice. It is available through The Jackson Laboratory, Stock #004435.

According to Professor Double, one of these factors may be a faulty version of the SOD1 protein, which can damage brain cells. Exploring the science behind the loss of smell in Parkinson’s patients ...

SOD1-ALS is one of the most aggressive forms of familiar ALS that is found in approximately 20% of familial forms of ALS and about 5% of the sporadic forms of ALS (depending on the demographic) (1).

Copper, zinc superoxide dismutase (SOD1) is activated in vivo by the copper chaperone for superoxide dismutase (CCS). The molecular mechanisms by which CCS recognizes and docks with SOD1 for metal ion ...

OBJECTIVE To understand the mechanisms causing neuronal death in amyotrophic lateral sclerosis (ALS), an electrophysiological technique of motor unit number estimation (MUNE) was used to examine the ...