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med's go on Instagram: "When a patient develops urticaria, bronchospasm, or anaphylaxis immediately after exposure to penicillin, it represents a Type I hypersensitivity reaction. This mechanism is IgE-mediated: the drug (hapten) binds to proteins and cross-links IgE on the surface of mast cells and basophils, leading to degranulation and release of histamine, leukotrienes, and other mediators. The rapid onset of symptoms (minutes to hours) and the clinical presentation of allergy (wheezing, hiv
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