How long does it take to restore normal dopamine levels? How long does it take for your dopamine system to bounce back after using cocaine especially if you’re sniffing a gram a week for a minimum of 6 months? Even at that “once-a-week” level, it still causes significant disruption to your dopamine system. What I’ve seen clinically and what the neuroscience confirms is that low-frequency use doesn’t mean low impact. Downregulation of D2 dopamine receptors Blunted reward sensitivity Impaired exec